Hi, Juby, I will give you my thoughts until the others with more info chime in. I am not on Xanax but I am on a medication for my heart that is listed as a medication you should not eat grapefruit with. This can increase your risk of side effects. Drug interactions Xanax and Valium are in the same drug class, so they have many of the same interactions with other drugs and substances. Grapefruit and grapefruit juice may interact with alprazolam and lead to unwanted side effects. Discuss the use of grapefruit products with your doctor. Discuss the use of grapefruit products with your doctor. Xanax is the brand name of alprazolam, a prescription drug used to treat anxiety disorders. Xanax is prescribed for generalized anxiety disorder (GAD), anxiety associated with depression, and. Find patient medical information for Grapefruit on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Drinking grapefruit juice while taking some sedative medications can increase the effects and side effects of some sedative medications. br/ br/ Some sedative medications that might interact. Side effects to XANAX Tablets, if they occur, are generally observed at the beginning of therapy and usually disappear upon continued medication. In the usual patient, the most frequent side effects are likely to be an extension of the pharmacological activity of alprazolam , eg, drowsiness or lightheadedness. Xanax (Alprazolam) is known interact with grapefruit and its juice and can cause certain side effects that may prove dangerous. Although many people are aware that grapefruit with many prescription medications when they are ingested together, very few understand the actual chemistry behind it or the effects they may experience. In turn, it could increase the side effects of Xanax like fatigue, dizziness, memory problems, poor coordination, irritability or blurred vision. You should not mix the two without discussing it first with your healthcare team. Wrong. Grapefruit juice is a POTENT disruptor of the metabolic cycle that removes Xanax from your body. Drinking grapefruit juice before or during ingestion of Xanax will in most cases increase the effects of Xanax and the duration of these effects.